Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.
Identifieur interne : 001384 ( Main/Exploration ); précédent : 001383; suivant : 001385Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.
Auteurs : RBID : pubmed:20945463English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Indium.
- metabolism : Germ Cells, Testis.
- ultrastructure : Germ Cells, Testis, Vacuoles.
- Animals, Body Weight, Male, Microscopy, Electron, Transmission, Rats, Rats, Wistar.
Abstract
Indium, a IIIA group element of the periodic chart, has many medical uses for diagnostic and clinical investigations in humans. This element is also used in industry and in nuclear fields where released streams can contaminate environment. Consequently, indium can reach humans mainly by natural ways. In this work, we attempted to study the incidence of this element on the food intake and body and testicle weights of rat, as well as the histological and the ultrastructural consequences of its presence in testicles using conventional transmission electron microscopy. Our study showed that this element induced a significant decrease in the food intake and body and testicles weights and caused necrosis and vacuolization in germinal cells. The ultrastructural observations showed the presence of electron-dense deposits characteristic of indium in the lysosomes of Leydig and Sertoli cells as well as sufferance in mitochondria of indium-treated rats. Despite the role of lysosome in the protection of living cells, by sequestration and concentration of indium in testicle cells under insoluble form, it is probable that this element has noxious effects on food intake and body and testicles weight and induces necrosis on seminal tissues of treated rats.
DOI: 10.1002/jemt.20945
PubMed: 20945463
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.</title><author><name sortKey="Samira, Maghraoui" uniqKey="Samira M">Maghraoui Samira</name><affiliation wicri:level="1"><nlm:affiliation>Physiology Laboratory, Medical School of Tunis, La Rabta, Tunis, Tunisia. maghraoui.samira@gmail.com</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Physiology Laboratory, Medical School of Tunis, La Rabta, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Ahlem, Ayadi" uniqKey="Ahlem A">Ayadi Ahlem</name></author><author><name sortKey="Aouatef, Ben Ammar" uniqKey="Aouatef B">Ben Ammar Aouatef</name></author><author><name sortKey="Habib, Jaafoura Mohamed" uniqKey="Habib J">Jaafoura Mohamed Habib</name></author><author><name sortKey="Leila, Tekaya" uniqKey="Leila T">Tekaya Leila</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1002/jemt.20945</idno><idno type="RBID">pubmed:20945463</idno><idno type="pmid">20945463</idno><idno type="wicri:Area/Main/Corpus">001747</idno><idno type="wicri:Area/Main/Curation">001747</idno><idno type="wicri:Area/Main/Exploration">001384</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Germ Cells (metabolism)</term><term>Germ Cells (ultrastructure)</term><term>Indium (metabolism)</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Rats</term><term>Rats, Wistar</term><term>Testis (metabolism)</term><term>Testis (ultrastructure)</term><term>Vacuoles (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Germ Cells</term><term>Testis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Germ Cells</term><term>Testis</term><term>Vacuoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Indium, a IIIA group element of the periodic chart, has many medical uses for diagnostic and clinical investigations in humans. This element is also used in industry and in nuclear fields where released streams can contaminate environment. Consequently, indium can reach humans mainly by natural ways. In this work, we attempted to study the incidence of this element on the food intake and body and testicle weights of rat, as well as the histological and the ultrastructural consequences of its presence in testicles using conventional transmission electron microscopy. Our study showed that this element induced a significant decrease in the food intake and body and testicles weights and caused necrosis and vacuolization in germinal cells. The ultrastructural observations showed the presence of electron-dense deposits characteristic of indium in the lysosomes of Leydig and Sertoli cells as well as sufferance in mitochondria of indium-treated rats. Despite the role of lysosome in the protection of living cells, by sequestration and concentration of indium in testicle cells under insoluble form, it is probable that this element has noxious effects on food intake and body and testicles weight and induces necrosis on seminal tissues of treated rats.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20945463</PMID><DateCreated><Year>2011</Year><Month>05</Month><Day>23</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0029</ISSN><JournalIssue CitedMedium="Internet"><Volume>74</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Microscopy research and technique</Title><ISOAbbreviation>Microsc. Res. Tech.</ISOAbbreviation></Journal><ArticleTitle>Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.</ArticleTitle><Pagination><MedlinePgn>546-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jemt.20945</ELocationID><Abstract><AbstractText>Indium, a IIIA group element of the periodic chart, has many medical uses for diagnostic and clinical investigations in humans. This element is also used in industry and in nuclear fields where released streams can contaminate environment. Consequently, indium can reach humans mainly by natural ways. In this work, we attempted to study the incidence of this element on the food intake and body and testicle weights of rat, as well as the histological and the ultrastructural consequences of its presence in testicles using conventional transmission electron microscopy. Our study showed that this element induced a significant decrease in the food intake and body and testicles weights and caused necrosis and vacuolization in germinal cells. The ultrastructural observations showed the presence of electron-dense deposits characteristic of indium in the lysosomes of Leydig and Sertoli cells as well as sufferance in mitochondria of indium-treated rats. Despite the role of lysosome in the protection of living cells, by sequestration and concentration of indium in testicle cells under insoluble form, it is probable that this element has noxious effects on food intake and body and testicles weight and induces necrosis on seminal tissues of treated rats.</AbstractText><CopyrightInformation>Copyright © 2010 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Samira</LastName><ForeName>Maghraoui</ForeName><Initials>M</Initials><Affiliation>Physiology Laboratory, Medical School of Tunis, La Rabta, Tunis, Tunisia. maghraoui.samira@gmail.com</Affiliation></Author><Author ValidYN="Y"><LastName>Ahlem</LastName><ForeName>Ayadi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Aouatef</LastName><ForeName>Ben Ammar</ForeName><Initials>BA</Initials></Author><Author ValidYN="Y"><LastName>Habib</LastName><ForeName>Jaafoura Mohamed</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Leila</LastName><ForeName>Tekaya</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>10</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Microsc Res Tech</MedlineTA><NlmUniqueID>9203012</NlmUniqueID><ISSNLinking>1059-910X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Body Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Germ Cells</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Testis</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Vacuoles</DescriptorName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>7</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>8</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/jemt.20945</ArticleId><ArticleId IdType="pubmed">20945463</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001384 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001384 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20945463
|texte= Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20945463" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |